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Levomilnacipran Dosage

The starting dosage of levomilnacipran for treating major depressive disorder is usually 20 mg once daily. This amount can be gradually increased if it does not adequately control depression symptoms. However, the maximum dose should not exceed 120 mg daily. Those who have kidney problems may need to take a lower amount.

An Introduction to Your Dosage of Levomilnacipran

The dose of levomilnacipran (Fetzima™) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to levomilnacipran
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Levomilnacipran Dosing Guidelines

The usual recommended starting dose of levomilnacipran for treating major depression is 20 mg once daily for two days. After two days, the amount will be increased to 40 mg a day.
Your healthcare provider may choose to increase your dose further based on how you respond to and tolerate the medication. If your dosage is increased, it will normally be increased by 40 mg at a time, no more often than every two days. Amounts above 120 mg a day are not recommended.
You should know that it can take several weeks, if not more than a month, for this medication to work completely. Therefore, your healthcare provider may recommend you continue taking it even if it does not seem to be working right away.

What's the Dose for People With Kidney Disease?

People with moderate kidney disease should generally not receive more than 80 mg of levomilnacipran a day. For people with severe kidney disease, the maximum recommended dosage is 40 mg a day. Levomilnacipran is not recommended for use in people with end-stage kidney disease.
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