Mental Health Channel
Topics & Medications
Quicklinks
Related Channels

Drug Interactions With Levomilnacipran

More Detail on Drug Interactions With Levomilnacipran

The following sections explain in detail the potentially negative interactions that can occur when levomilnacipran is combined with any of the drugs listed above.
 
Alcohol
Taking levomilnacipran with alcohol could cause the drug to be released into your blood too quickly, potentially increasing your risk for side effects. You should not drink alcohol during levomilnacipran treatment.  
 
CYP 3A4 Inducer Medications
The liver breaks down levomilnacipran using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining levomilnacipran with one of these drugs may decrease the level of levomilnacipran in your body, potentially making it less effective. Normally, this interaction only causes small changes in levomilnacipran blood levels, so it is usually not necessary to change your dose if these medications are taken together.
 
CYP 3A4 Inhibitor Medications
The liver breaks down levomilnacipran using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining levomilnacipran with one of these drugs may increase the level of levomilnacipran in your body, potentially increasing your risk for side effects. In some cases, it may be necessary to reduce your levomilnacipran dosage so you're taking no more than 80 mg a day if you are taking it with certain CYP 3A4 inhibitors.
 
Diuretics
Levomilnacipran can cause low blood sodium levels (known medically as hyponatremia). Taking it with a diuretic may increase your risk for this side effect. Talk to your healthcare provider before taking these medications together.
 
Medications That Thin the Blood
Taking levomilnacipran with medications that increase the risk for bleeding can further increase your risk for dangerous internal bleeding. Talk to your healthcare provider before taking these drugs together. Contact your healthcare provider if you develop any signs of bleeding while taking levomilnacipran, including:
 
  • Weakness
  • Abdominal (stomach) pain
  • Black, tarry stools
  • Vomit that looks like coffee grounds.
 
Monoamine Oxidase Inhibitors 
Taking an MAOI with levomilnacipran can cause a life-threatening side effect known as serotonin syndrome. Serotonin syndrome can lead to a variety of serious symptoms, such as:
 
 
You should not take levomilnacipran if you have taken an MAOI within the past 14 days. You should also wait at least seven days after taking your last levomilnacipran dose before taking an MAOI.
 
Other Medications That Affect Serotonin
Taking levomilnacipran with other medications that increase serotonin levels could cause a rare but life-threatening reaction known as serotonin syndrome. Serotonin syndrome can lead to a variety of serious symptoms. Talk to your healthcare provider before taking levomilnacipran with other medicines that affect serotonin.
 
5 Common Relationship Mistakes for Adults With ADHD

Levomilnacipran Drug Information

Terms of Use
Advertise with Us
Contact Us
About eMedTV
Privacy Policy
Copyright © 2006-2017 Clinaero, Inc.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.