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L-Tryptophan Drug Interactions

L-Tryptophan Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when L-tryptophan is combined with any of the drugs listed above.
 
Antidepressants
Taking L-tryptophan with prescription antidepressants can cause a group of symptoms called serotonin syndrome. This is a group of dangerous symptoms that includes:
 
  • Confusion
  • Hallucinations
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasms
  • Difficulty walking
  • Diarrhea.
 
Talk to your healthcare provider before taking L-tryptophan and a depression medication together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
Benzodiazepines
Combining L-tryptophan with a benzodiazepine may cause problems such as sexual side effects or uncontrollable muscle movements. Check with your healthcare provider before taking these medications together.
 
Meperidine (Demerol)
Taking meperidine with L-tryptophan may increase the risk of serotonin syndrome. Do not combine these drugs without your healthcare provider's approval.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking L-tryptophan and an MAOI together can cause life-threatening side effects. Never take these medications together.
 
Phenothiazines
Combining L-tryptophan with a phenothiazine may cause problems such as sexual side effects or uncontrollable muscle movements. Check with your healthcare provider before taking these medications together.
 
St. John's Wort
Taking L-tryptophan with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these products together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
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