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Is L-Methylfolate Safe?

If you are considering using L-methylfolate, make sure your healthcare provider is aware of any other medical conditions you have, such as anemia, colon cancer, or a seizure disorder. Other safety concerns with L-methylfolate include possible drug interactions and allergic reactions. Also, check with your healthcare provider or pharmacist about which product is made by a trustworthy manufacturer.

Is It Safe to Take L-Methylfolate?

When used appropriately, L-methylfolate is probably safe for most people. However, some people may be more likely to experience problems than others. Therefore, you should talk with your healthcare provider prior to taking L-methylfolate if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific L-Methylfolate Safety Warnings and Precautions

Some warnings and precautions to be aware of concerning the safety of L-methylfolate include the following:
  • L-methylfolate is regulated as a dietary supplement or medical food. Regulations for dietary supplements and medical foods are not as rigorous as those for prescription and nonprescription drugs. Make sure to choose an L-methylfolate supplement from a reliable manufacturer. Your healthcare provider or pharmacist may be able to recommend one for you.
  • If you are pregnant or breastfeeding, it is always a good idea to check with your healthcare provider before taking any medication, including dietary supplements (see L-Methylfolate and Pregnancy and L-Methylfolate and Breastfeeding). At normal dosages, L-methylfolate is considered safe for women who are pregnant or breastfeeding.
  • L-methylfolate can mask anemia caused by vitamin B12 deficiency. This means it will be more difficult to determine if you have B12 deficiency from simple blood tests. Because vitamin B12 deficiency can cause nerve damage if left untreated, your healthcare provider may test you for anemia before you start taking L-methylfolate.
  • High doses of folic acid may increase the risk of seizures in people with a seizure disorder. L-methylfolate may have the same risk. Therefore, talk to your healthcare provider before taking L-methylfolate if you have a seizure disorder.
  • Large doses of folic acid may accelerate the growth of colon tumors. It is unclear if L-methylfolate, the active form of folic acid, has the same effect on colon tumors. If you have cancer of the colon, talk to your healthcare provider before taking this vitamin.
  • L-methylfolate is safe for pregnant women at normal doses. Talk to your healthcare provider about the risks and benefits of using L-methylfolate during pregnancy (see L-Methylfolate and Pregnancy).
  • It is unknown if L-methylfolate passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the supplement (see L-Methylfolate and Breastfeeding).
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L-Methylfolate Information

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