Drug Interactions With Iloperidone

The following sections explain in detail the potentially negative interactions that can occur due to iloperidone drug interactions.

 

Combining iloperidone with alcohol or medications that cause drowsiness can lead to undesirable or even potentially dangerous side effects (such as extreme drowsiness, "passing out," confusion, or impaired breathing). You should not drink alcohol while taking iloperidone. Check with your healthcare provider before combining iloperidone with any other medication that causes drowsiness.

 

Taking iloperidone with a high blood pressure medication might increase the risk of low blood pressure. Make sure to watch for signs of this problem, such as lightheadedness, dizziness, or fainting.

 

Iloperidone is metabolized by a specific liver enzyme known as CYP 2D6. Some other medications (known as CYP 2D6 inhibitors) slow down the activity of this enzyme, causing an increase in the level of iloperidone in the blood. This could potentially lead to serious iloperidone effects. When combining iloperidone with strong CYP 2D6 inhibitors (such as the ones listed in this article), the iloperidone dosage should be reduced by half.

 

Iloperidone is metabolized by a specific liver enzyme known as CYP 3A4. Some other medications (known as CYP 3A4 inhibitors) slow down the activity of this enzyme, causing an increase in the level of iloperidone in the blood. This could potentially lead to serious iloperidone effects. When combining iloperidone with strong CYP 3A4 inhibitors (such as the ones listed in this article), the iloperidone dosage should be reduced by half.