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Precautions and Warnings With Fluvoxamine CR

There are several precautions and warnings with fluvoxamine CR to be aware of before starting treatment, including information on who should not use the drug. You should not take this medication if you are allergic to any of its components or have recently taken an MAOI. Warnings and precautions with fluvoxamine CR also apply to people who have bipolar disorder, epilepsy, or any allergies.

Fluvoxamine CR: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking fluvoxamine CR (Luvox® CR) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding
  • Smoke cigarettes.
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions for Fluvoxamine CR

Some warnings and precautions to be aware of prior to taking fluvoxamine CR include the following:
  • Fluvoxamine CR can interact with many medicines (see Drug Interactions With Fluvoxamine CR). Many of these interactions are serious. Always check with your healthcare provider before taking any medications (including non-prescription medications) with fluvoxamine CR.
  • Even though fluvoxamine CR is not licensed to treat depression, it is classified as an antidepressant based on how it works in the brain. Antidepressants may increase the risk of suicidal thinking or behavior in children, teenagers, and adults (see Depression and Suicide for more information). Therefore, if you notice any changes in symptoms or new symptoms, talk to your healthcare provider immediately. Some of these symptoms may include:
    • Anxiety
    • Hostility
    • Agitation
    • Panic
    • Restlessness
    • Hallucinations
    • Extreme hyperactivity
    • Suicidal thinking or behavior.
  • Before prescribing fluvoxamine CR off-label for depression, your healthcare provider should make sure you do not have bipolar disorder instead. Sometimes, the symptoms of bipolar disorder and depression are similar, and fluvoxamine CR can cause problems in people with bipolar disorder.
  • Smoking usually decreases the level of fluvoxamine CR in your blood. If you start smoking (or quit smoking), your healthcare provider may need to adjust your fluvoxamine CR dosage.
  • If you have a seizure disorder, there is a possibility that taking fluvoxamine CR may cause seizures. Talk to your healthcare provider before taking this drug if you have seizures.
  • If you are stopping fluvoxamine CR, you should be monitored by a healthcare provider for withdrawal symptoms. If you do develop any symptoms of withdrawal, such as irritability, anxiety, confusion, headache, lethargy, or insomnia, your healthcare provider may slow down the rate at which the medication is stopped.
  • Fluvoxamine CR may cause bleeding in the stomach or intestines. This risk is increased in those taking aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. Symptoms of gastrointestinal bleeding may include:
    • Bright red blood coating the stool
    • Dark blood mixed with the stool
    • Black or tarry stool
    • Bright red blood in vomit
    • Vomit that has the appearance of coffee grounds.
 If you experience any of these symptoms, call your healthcare provider right away.
  • Taking fluvoxamine CR with other medications that affect serotonin can increase your risk of a dangerous group of symptoms called serotonin syndrome. These medications include other antidepressants, triptans (migraine medications), and several other medications (see Drug Interactions With Fluvoxamine CR for more information). Contact your healthcare provider immediately if you have any possible symptoms of serotonin syndrome, including:
    • Confusion
    • Seeing or hearing things that are not really there (hallucinations)
    • Fast heartbeat (tachycardia)
    • Feeling faint
    • Fever
    • Sweating
    • Muscle spasms
    • Difficulty walking
    • Diarrhea.
  • If you are elderly or taking a diuretic, fluvoxamine CR could cause low salt levels in the blood (hyponatremia). This generally returns to "normal" when the medication is stopped.
  • If you have liver problems, you may need a lower fluvoxamine CR dose (and your dose should be increased slowly and only if needed), since the liver helps to remove fluvoxamine CR from the blood.
  • This medication may affect your ability to perform complex tasks requiring mental and motor skills. Therefore, you should become accustomed to its effect on you before becoming involved in activities requiring mental or motor concentration, such as driving a car or operating machinery. This effect may be greater if you are taking other medications that make you drowsy.
  • Fluvoxamine CR is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy. Talk to your healthcare provider about the risks and benefits of taking the drug when pregnant (see Luvox CR and Pregnancy for more information).
  • Fluvoxamine CR passes through breast milk. Therefore, if you are breastfeeding or plan to start, be sure to talk with your healthcare provider before using the drug (see Luvox CR and Breastfeeding).
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Fluvoxamine CR Information

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