Drug Interactions With Fluvoxamine CR
Fluvoxamine CR can increase the level of mexiletine in your blood. Your healthcare provider should monitor your blood levels, especially when starting or stopping fluvoxamine CR.
Combining fluvoxamine CR with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
Monoamine Oxidase Inhibitors (MAOIs)
Taking fluvoxamine CR and an MAOI together can cause life-threatening side effects. Never take an MAOI and fluvoxamine CR at the same time, and do not take them within two weeks of each other.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Combining fluvoxamine CR and NSAIDs together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking these medications together.
Phenytoin (Dilantin, Phenytek)
Fluvoxamine CR can increase the level of phenytoin in your blood, possibly increasing your risk of side effects. Your healthcare provider should monitor the level of phenytoin in your blood, especially when you are starting or stopping fluvoxamine CR.
Pimozide and fluvoxamine CR should not be taken together, as the combination may cause a dangerous irregular heart rhythm (arrhythmia) called QT prolongation. Do not take these two medications together.
Propranolol (Inderal, Inderal LA, Innopran XL)
Fluvoxamine CR can increase the level of propranolol in your blood, perhaps increasing your risk of side effects. Your healthcare provider may need to adjust your dose of propranolol to prevent this drug interaction from occurring.