Drug Interactions With Elavil

Some of the drugs that can potentially interact with Elavil include other tricyclic antidepressants, alcohol, barbiturates, phenothiazine medications, and thyroid medications. Drug interactions with Elavil can cause delirium and increase your risk of suicidal thoughts or side effects like drowsiness or dizziness, among other things. It is important to talk with your healthcare provider about any Elavil drug interactions that may apply to you.

 

Elavil Drug Interactions: An Introduction

Elavil® (amitriptyline hydrochloride) can potentially interact with many drugs. Some of the drugs that may lead to Elavil interactions include:
 
  • Anticholinergic medications, including:
o Atropine
o Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
o Clidinium (Librax®)
o Dicyclomine (Bentyl®)
o Diphenhydramine (Benadryl®, Tylenol PM®)
o Glycopyrrolate (Robinul®)
o Homatropine (Hycodan®)
o Hyoscyamine (Levsin®)
o Scopolamine (Transderm Scop®)
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®).
  • Cimetidine (Tagamet®)
     
  • Cisapride (Propulsid®)
     
  • Flecainide (Tambocor®)
     
  • Monoamine oxidase inhibitors (MAOIs), including:
  • Phenothiazine medications, including:
o Promethazine (Phenergan®)
  • Pressors, including:
o Dopamine (Intropin®)
o Dobutamine (Dobutrex®)
o Epinephrine (Adrenalin®, EpiPen®)
o Norepinephrine (Levophed®).
  • Propafenone (Rythmol®)
     
  • Quinidine
     
  • Disulfiram (Antabuse®)
     
  • SSRI antidepressants, including:
  • Thyroid medications, including:
o Liothyronine (Cytomel®)
o Liotrix (Thyrolar®)
o Levothyroxine (Levoxyl®, Synthroid®, Unithroid®)
o Thyroid (Armour® Thyroid, Nature-Throid®).
  • Alcohol.
     
(Drug Interactions With Elavil Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;