Drug Interactions With Docosahexaenoic Acid (Cont.)

 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)
Theoretically, taking an NSAID with fish oil (which contains docosahexaenoic acid) may increase the risk of bleeding. It is not clear if docosahexaenoic acid alone also causes this problem. If you take an NSAID regularly, you may want to check with your healthcare provider before taking docosahexaenoic acid.
 
Orlistat (Alli, Xenical)
Orlistat works by blocking the absorption of fat into your body. This action could block the absorption of docosahexaenoic acid into the body. To avoid this problem, be sure to take orlistat and your docosahexaenoic acid supplement at least two hours apart.
 
Warfarin (Coumadin, Jantoven)
It is possible that warfarin may interact with fish oil (which contains docosahexaenoic acid), increasing your risk of bleeding. It is not yet known how significant this interaction may be or if it applies to docosahexaenoic acid as well. Check with your healthcare provider before taking warfarin and docosahexaenoic acid together.
 

Final Thoughts on Docosahexaenoic Acid Drug Interactions

It is possible that not every drug interaction with docosahexaenoic acid was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the docosahexaenoic acid interactions that may apply to you.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;