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Drug Interactions With Docosahexaenoic Acid

Docosahexaenoic Acid Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when docosahexaenoic acid is combined with some of the drugs listed above.
Blood Pressure Medication
Taking fish oil (which contains docosahexaenoic acid) with high blood pressure medication may decrease your blood pressure too much, increasing the risk of low blood pressure (hypotension). However, it is not known if this interaction applies to docosahexaenoic acid alone.
Check with your healthcare provider before combining docosahexaenoic acid supplements with blood pressure medication, as your healthcare provider may need to monitor you more closely and adjust the dose of your blood pressure medication as necessary.
Medications That "Thin" the Blood
Combining docosahexaenoic acid with medications that increase the risk of bleeding (such as antiplatelet and anticoagulant medications) could, at least in theory, further increase the risk of bleeding, including dangerous internal bleeding.
Check with your healthcare provider before taking docosahexaenoic acid in combination with an anticoagulant or antiplatelet medication. Be sure to specifically discuss the possible bleeding risk. In many cases, your healthcare provider may recommend that it is okay to combine such medications, as long as you are careful to watch for any signs of easy bruising or bleeding.
Orlistat (Alli, Xenical)
Orlistat works by blocking the absorption of fat into your body. This action could block the absorption of docosahexaenoic acid into the body. To avoid this problem, be sure to take orlistat and your docosahexaenoic acid supplement at least two hours apart.
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