Drug Interactions With Dexmethylphenidate (Cont.)

Interactions With Dexmethylphenidate Explained

 
Clonidine (Catapres)
Taking dexmethylphenidate with clonidine can increase your risk of serious side effects. Your healthcare provider may need to adjust your doses of these medications.
 
MAO Inhibitors
Taking dexmethylphenidate and MAO inhibitors together can cause life-threatening side effects, such as very high blood pressure. Do not take dexmethylphenidate and MAO inhibitors together unless your healthcare provider specifically tells you to do so. Do not take Focalin if you have taken an MAO inhibitor within the past two weeks.
 
Pressors
Taking dexmethylphenidate and pressors together can cause an increase in side effects, particularly increased blood pressure and heart rate. Your healthcare provider may need to monitor your heart rate and blood pressure closely and adjust your doses of these drugs if necessary.
 
Seizure Medications
Taking dexmethylphenidate with seizure medications can increase the amount of the seizure medication in the blood, perhaps increasing your risk of side effects. Your healthcare provider may need to decrease your dose of the seizure medication.
 
SSRI Antidepressants
Taking dexmethylphenidate with SSRI antidepressants can increase the amount of the antidepressant in your blood, perhaps increasing your risk of side effects. Your healthcare provider may need to decrease your dose of the antidepressant.
 
Tricyclic Antidepressants
Taking dexmethylphenidate with tricyclic antidepressants can increase the amount of the antidepressant in your blood, perhaps increasing your risk of side effects. Your healthcare provider may need to decrease your dose of the antidepressant.
(Drug Interactions With Dexmethylphenidate Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;