You should talk with your healthcare provider prior to taking this medication if you have:
- Bipolar disorder or a family history of bipolar disorder (also known as manic depression)
- Heart disease
- A recent heart attack
- A history of suicide attempts or suicidal thoughts
- An upcoming surgery
- Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Trazodone and Pregnancy)
Make sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Desyrel Warnings and Precautions to learn more, including information on who should not take the drug.)
It is not entirely clear how Desyrel works, since no other medications work exactly like it. Desyrel acts on a specific chemical within the brain known as serotonin. This is one of several chemicals used to send messages in between nerves; however, when serotonin levels become unbalanced, it can cause a variety of conditions, including depression. Desyrel helps to block the reuptake of serotonin so that more is available for the nerves in the brain, returning the serotonin back to its "normal" levels. However, unlike selective serotonin reuptake inhibitors (SSRIs), Desyrel may also block certain serotonin receptors.