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Side Effects of Desvenlafaxine

Common Side Effects of Desvenlafaxine

Desvenlafaxine has been studied thoroughly in clinical trials. In these clinical trials, one group of people was given the real medication, while another group was given a placebo (a "sugar pill" with no active ingredients). This way, it is possible to see what side effects occurred, how often they appeared, and how they compared to the group who took the placebo.
In these studies, the most common side effects of desvenlafaxine (when taken at the recommended dose of 50 mg per day) included:
  • Nausea -- in up to 22 percent of people
  • Dizziness -- up to 13 percent
  • Dry mouth -- up to 11 percent
  • Diarrhea -- up to 11 percent
  • Increased sweating -- up to 10 percent.
Other common side effects (occurring in 2 to 9 percent of people) included but were not limited to:
  • Constipation
  • Fatigue
  • Decreased appetite
  • Weight loss
  • Insomnia
  • Irritability
  • Abnormal dreams
  • Blurred vision
  • Ringing in the ears (tinnitus)
  • Decreased sex drive (libido) in men
  • A spinning sensation (vertigo) 
  • Impotence (also known as erectile dysfunction or ED).

Less Common Side Effects of Desvenlafaxine

In studies, rare side effects of desvenlafaxine occurred in less than 2 percent of people taking the drug. Because these side effects are so uncommon, it is difficult to tell whether they are actually caused by desvenlafaxine or something else. There is a good chance that these "side effects" could be completely unrelated to the medication.
These less common side effects include but are not limited to:
  • Yawning
  • Hot flashes
  • Delayed ejaculation
  • Lack of orgasm in women or men
  • Nosebleeds
  • Increased LDL cholesterol ("bad" cholesterol).
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