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Drug Interactions With Desvenlafaxine

Sibutramine (Meridia)
Taking desvenlafaxine with a sibutramine can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before combining these medications. Contact your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
SSRI or SNRI Antidepressants
Combining desvenlafaxine with other SSRI or SNRI antidepressants can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these depression medications together. Contact your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Desvenlafaxine should never be combined with venlafaxine, as these medications are similar to each other.
 
St. John's Wort
Taking desvenlafaxine with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Contact your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
Combining desvenlafaxine with a tramadol can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Contact your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be dangerous.
 
Tricyclic Antidepressants
Taking desvenlafaxine with tricyclic antidepressants can increase the level of tricyclic antidepressants in your blood. Your healthcare provider may need to reduce your dose of the tricyclic antidepressant to prevent this drug interaction.
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