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Drug Interactions With Desvenlafaxine

Desvenlafaxine and Serotonin Syndrome

Several of the known interactions with desvenlafaxine are related to a potentially dangerous group of symptoms known as serotonin syndrome. Such symptoms might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
Serotonin syndrome usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking these medications together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

More Information on Interactions With Desvenlafaxine

The following sections explain in detail the potentially negative interactions that can occur when desvenlafaxine is combined with any of the drugs listed above.
People are usually advised to avoid alcohol while taking desvenlafaxine. Consuming alcohol with desvenlafaxine may cause unwanted side effects.
Anticoagulant or Antiplatelet Medications
Combining desvenlafaxine with medications that "thin" the blood (medications with anticoagulant or antiplatelet properties) could increase the risk of bleeding. Check with your healthcare provider before taking desvenlafaxine with any of these medications.
Buspirone (BuSpar)
Because combining desvenlafaxine with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
Ketoconazole (Nizoral)
Taking desvenlafaxine with ketoconazole may increase the level of desvenlafaxine in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to decrease your desvenlafaxine dosage to prevent this interaction from occurring.
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