Clozaril Drug Interactions

When certain medications are taken with Clozaril, drug interactions may occur. These interactions can alter the amount of the medications in your blood, potentially increasing your risk of side effects or making Clozaril less effective. Some of the medicines that can cause drug interactions with Clozaril include certain antibiotics, blood pressure medications, and certain anticonvulsants.

An Introduction to Clozaril Drug Interactions

 Clozaril® (clozapine) can potentially interact with a number of other medicines. Some of these medicines that may lead to Clozaril drug interactions include:
 
  • Benzodiazepines, such as:
 
 
 
 
  • Certain anticonvulsants, including:
 
 
 
 
  • Certain arrhythmia medications, including:
 
    • Propafenone (Rythmol®)
    • Flecainide (Tambocor®)
    • Quinidine
 
  • Medications that can cause a heart rhythm change known as QT prolongation (see QT-Prolonging Medications for a list of such medications)
  • Nicotine
  • Phenothiazine medications, including:
 
 
  • Rifamycin antibiotics, including:
 
    • Rifabutin (Mycobutin®)
    • Rifampin (Rifadin®)
    • Rifapentine (Priftin®).
 
Clozaril Drug Interactions Article Continues on Next Page >
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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