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Clozaril Drug Interactions

Cimetidine
If Clozaril and cimetidine are combined, this can increase the level of Clozaril in your blood, increasing your risk of Clozaril side effects. Your healthcare provider may need to lower your Clozaril dose to prevent this from occurring.
 
Nicotine
Taking Clozaril with nicotine can decrease the level of Clozaril in your blood, perhaps making it less effective. Your healthcare may need to increase your Clozaril dosage as a result.
 
Phenothiazines
If Clozaril is taken with a phenothiazine, it can increase the level of both medications in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower your dose of Clozaril and the phenothiazine as a result.
 
Quinidine
Taking Clozaril with quinidine can increase the level of both medications in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your dose of Clozaril and the quinidine to prevent this drug interaction from occurring.

QT-Prolonging Medications
There have been reports of a certain change in heart rhythm (known as QT prolongation) in people taking Clozaril. This heart rhythm change can be dangerous. Check with your healthcare provider before combining Clozaril with other QT-prolonging medications.
 
Rifamycin Antibiotics
Taking Clozaril with a rifamycin antibiotic can decrease the level of Clozaril in your blood, perhaps making it less effective. Your healthcare may need to increase your Clozaril dosage to prevent this.
 

Final Thoughts on Clozaril Drug Interactions

Not every drug interaction with Clozaril was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific Clozaril drug interactions that may apply to you.
 
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Clozaril Drug Information

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