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Drug Interactions With Clozapine Oral Suspension

More Detail on Drug Interactions With Clozapine Oral Suspension

The following sections explain in detail the potentially negative interactions that can occur when clozapine oral suspension is combined with any of the drugs listed above.
 
Blood Pressure Medications
Clozapine oral suspension can cause low blood pressure. If you take it with blood pressure medicines, your healthcare provider may choose to monitor your blood pressure more closely to make sure it doesn't drop too low.
 
Carbamazepine
Clozapine oral suspension may increase blood levels of carbamazepine, which could increase your risk for side effects. In addition, carbamazepine may decrease blood levels of clozapine oral suspension. Your healthcare provider will need to monitor you closely if you take these medicines together, and may need to adjust your doses.
 
Certain Antidepressant Medications
Combining clozapine oral suspension with certain antidepressants can increase the level of clozapine oral suspension in your blood, possibly increasing your risk for side effects. In addition, clozapine oral suspension may increase blood levels of certain antidepressant medicines. Your healthcare provider may need to adjust your doses if you take these drugs together.
 
Certain Arrhythmia Medicines
Clozapine oral suspension can increase blood levels of certain arrhythmia medicines, potentially increasing your risk for serious side effects. Your healthcare provider may need to monitor you more closely, and possibly lower the dose of your arrhythmia medicine, if you take these products together. 
 
CYP 1A2 Inhibitor Medications
The liver breaks down clozapine oral suspension using enzymes known as CYP 1A2 enzymes, and medications known as CYP 1A2 inhibitors can decrease the activity of these enzymes. Thus, combining clozapine oral suspension with one of these drugs may increase the level of clozapine oral suspension in your body, increasing your risk for side effects. Your healthcare provider will monitor you more closely and adjust your clozapine oral suspension dosage, especially when you first start or stop a CYP 1A2 inhibitor.
 
CYP 2D6 Inhibitor Medications
The liver breaks down clozapine oral suspension using enzymes known as CYP 2D6 enzymes, and medications known as CYP 2D6 inhibitors can decrease the activity of these enzymes. Thus, combining clozapine oral suspension with one of these drugs may increase the level of clozapine oral suspension in your body, increasing your risk for side effects. Your healthcare provider will monitor you more closely and may need to adjust your clozapine oral suspension dose, especially when you first start or stop taking a CYP 2D6 inhibitor.
 
CYP 3A4 Inducer Medications
The liver breaks down clozapine oral suspension using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining clozapine oral suspension with one of these drugs may decrease the level of clozapine oral suspension in your body, possibly making it less effective. Your healthcare provider may need to monitor you more closely if you take these medications together.
 
CYP 3A4 Inhibitor Medications
The liver breaks down clozapine oral suspension using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining clozapine oral suspension with one of these drugs may increase the level of clozapine oral suspension in your body, increasing your risk for side effects. Your healthcare provider will monitor you more closely and may need to adjust your clozapine oral suspension dose, especially when you first start or stop taking a CYP 3A4 inhibitor.
 
QT-Prolonging Medications
Clozapine oral suspension may cause a certain potentially dangerous change in the heart rhythm known as QT prolongation. Talk to your healthcare provider before taking clozapine oral suspension with another QT-prolonging medication.
 
Phenothiazine Medications
Taking clozapine oral suspension with a phenothiazine can increase the level of both medications in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to adjust your doses if you take these medications together.
 
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Clozapine Oral Suspension Information

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