Clozapine Oral Suspension
Clozapine, the active ingredient in clozapine oral suspension, has been studied in clinical trials. In these studies, researchers looked at the effects of clozapine for treating symptoms of schizophrenia, as well as the drug's effect on suicidal behavior in people with schizophrenia.
Using Clozapine to Treat Schizophrenia
In one clinical study, people with schizophrenia that had not adequately responded to treatment with at least three different antipsychotics were given either clozapine or an older antipsychotic known as chlorpromazine (Thorazine®). After six weeks of treatment, 30 percent of people given clozapine had responded to it by having a meaningful reduction in their symptoms, including hallucinations, suspiciousness, and unusual thoughts. In comparison, only 4 percent of people given chlorpromazine responded to that medication.
Using Clozapine for Suicidal Behavior in People With Schizophrenia
In another study, people who were at risk for suicidal behavior because they had previously attempted suicide, been hospitalized to prevent suicide, or demonstrated suicidal thoughts were given clozapine. Clozapine reduced the chance that someone would attempt suicide or be hospitalized because of suicidal risk.
Clozapine oral suspension belongs to a group of medicines known as atypical antipsychotics (also called second-generation antipsychotics). It is thought to work by blocking the action of dopamine, a neurotransmitter chemical in the brain that is believed to be elevated in people with schizophrenia.
Like other atypical antipsychotics, clozapine oral suspension also blocks a type of serotonin receptor. Serotonin is another brain chemical, and blocking this receptor is thought to help control some of the symptoms of schizophrenia.