Clozapine Oral Suspension Dosage
When treating schizophrenia with clozapine oral suspension, dosing guidelines will be based on how you respond to the medicine, other drugs you are taking, and various other factors. This medication comes as a liquid that is taken once or twice daily. The starting amount is usually 25 mg taken once or twice a day. This amount can be increased slowly up to a maximum of 900 mg a day.
The dose of clozapine oral suspension (Versacloz™) your healthcare provider recommends will vary, depending on a number of factors, including:
- How you respond to the medication
- Other medical conditions you may have
- Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
The recommended initial dose of clozapine oral suspension for the treatment of schizophrenia is usually 25 mg taken once or twice a day. This is just a starting dose. If you tolerate the medication, your healthcare provider will slowly increase this amount to the usual effective dose of 300 mg to 450 mg per day, usually within two weeks.
Doses are normally increased by 25 mg to 50 mg each day, or 100 mg once or twice a week. Clozapine oral suspension must be started at a low dose and increased slowly to minimize the risk for dangerously low blood pressure, heart rate, and fainting.
Some people may need to be treated with higher amounts. The maximum recommended clozapine oral suspension dose is 900 mg a day, taken in two doses.
People taking certain other medications will need to be treated with lower doses (see Drug Interactions With Clozapine Oral Suspension). People with kidney or liver disease may also need lower amounts.
Clozapine oral suspension can cause dangerously low levels of white blood cells (agranulocytosis). In order to take the drug, you will need a blood test to check the number of white blood cells in your body prior to starting treatment and periodically thereafter.
If you need to stop taking clozapine oral suspension, your healthcare provider will slowly decrease your dosage over a period of one to two weeks. You should not stop taking this medication suddenly unless your healthcare provider tells you to do so.
If you do need to abruptly stop treatment, which could happen if you are experiencing potentially dangerous clozapine oral suspension side effects, your healthcare provider will need to monitor you closely for potentially serious symptoms. These may include: