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Drug Interactions With Citalopram

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking citalopram and NSAIDs together can increase your risk of stomach bleeding. Talk to your healthcare provider before combining these products.
 
Pimozide (Orap)
Pimozide and citalopram should not be taken together, as the combination may cause a dangerous irregular heart rhythm (arrhythmia) called QT prolongation. Do not take these two medications together.
 
SSRI or SNRI Antidepressants
Taking citalopram with other SSRI or SNRI antidepressants can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of this condition, as it can be dangerous.
 
St. John's Wort
Taking citalopram with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any signs of this condition, as it can be dangerous.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
Taking citalopram with a tramadol can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of this condition, as it can be dangerous.
 
Tricyclic Antidepressants
Taking citalopram with a tricyclic antidepressant can increase the level of the tricyclic antidepressant in your blood. Your healthcare provider may need to reduce your dose of the tricyclic antidepressant.
 
Triptans
Taking citalopram with a triptan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of this condition, as it can be dangerous.
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