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Drug Interactions With Citalopram

Fentanyl
Combining citalopram with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking citalopram with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Ketoconazole (Nizoral)
Taking ketoconazole with citalopram may decrease the level of ketoconazole in your blood, perhaps making it less effective. Your healthcare provider may need to increase your ketoconazole dosage.
 
Linezolid (Zyvox)
Taking citalopram with a linezolid can increase the risk for serotonin syndrome. Talk to your healthcare provider before taking these drugs together. Call your healthcare provider right away if you have any possible symptoms, as serotonin syndrome can be dangerous.
 
Lithium (Eskalith, Lithobid)
Taking citalopram with lithium can increase the risk for serotonin syndrome. Talk to your healthcare provider before taking these drugs together. Call your healthcare provider right away if you have any possible symptoms, as serotonin syndrome can be dangerous.
 
Medications That Cause QT Prolongation
Citalopram (especially at higher doses) can sometimes cause a certain change in the heart rhythm known as QT prolongation. QT prolongation can lead to a very serious, potentially fatal arrhythmia. Combining citalopram with other medications that can also cause QT prolongation increases this risk. Check with your healthcare provider before taking such drugs together.
  
Metoprolol (Lopressor, Toprol XL)
Citalopram can increase the level of metoprolol in your blood, perhaps increasing your risk of side effects. Your healthcare provider may need to adjust your metoprolol dosage.
 
Miscellaneous Antidepressants
Combining citalopram with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of this condition, as it can be dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking citalopram and an MAOI together can cause life-threatening side effects. Never take these medications at the same time, and do not take them within two weeks of each other.
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