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Drug Interactions With Citalopram

Citalopram and Serotonin Syndrome

Several of the known interactions with citalopram are related to a potentially dangerous group of symptoms known as serotonin syndrome. Signs might include:
  • Confusion
  • Hallucination
  • Fast heartbeat
  • Feeling faint
  • Fever
  • Sweating
  • Muscle spasm
  • Difficulty walking
  • Diarrhea.
This condition usually occurs when people take more than one medication that affects serotonin at the same time. Talk to your healthcare provider before taking such drugs together. In many cases, such combinations are still recommended, although with more careful monitoring. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.

More Details on Drug Interactions With Citalopram

The following sections explain in detail the potentially negative interactions that can occur when citalopram is combined with any of the drugs listed above.
People are generally advised to avoid alcohol while taking citalopram. Combining the two may cause unwanted side effects (see Alcohol and Citalopram).
Taking citalopram and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking these drugs together.
Buspirone (BuSpar)
Because combining citalopram with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
CYP 2C19 Inhibitors
The body breaks down ("metabolizes") citalopram using specific liver enzymes known as CYP 2C19 enzymes. Drugs known as CYP 2C19 inhibitors can slow down the activity of these enzymes and can significantly increase the level of citalopram in the body. This may increase the risk of dangerous side effects. For people taking a CYP 2C19 inhibitor medication, the maximum recommended citalopram dosage is 20 mg a day.
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