Drug Interactions With Chlordiazepoxide and Amitriptyline

Certain medicines can cause drug interactions with chlordiazepoxide and amitriptyline, such as sleep medications, narcotics or opiates, and other antidepressants. To reduce your risk of developing drug interactions, make sure to tell your healthcare provider about all medications you are taking. Drug interactions with chlordiazepoxide and amitriptyline may lead to drowsiness, confusion, memory loss, or difficulty breathing.

 

Drug Interactions With Chlordiazepoxide and Amitriptyline: An Overview

Chlordiazepoxide and amitriptyline (Limbitrol®) can potentially interact with numerous other medications, especially those that affect the brain. Some of the medicines that may lead to chlordiazepoxide and amitriptyline drug interactions include:
 
  • Alcohol
 
  • Anticholinergic medications, such as:
o Atropine
o Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
o Clidinium (Librax®)
o Clozapine (Clozaril®, FazaClo®)
o Dicyclomine (Bentyl®)
o Diphenhydramine (Benadryl®, Tylenol PM®)
o Glycopyrrolate (Robinul®)
o Homatropine (Hycodan®)
o Hyoscyamine (Levsin®)
o Scopolamine (Transderm Scop®)
  • Antipsychotic medications, such as:
o Clozapine (Clozaril®, FazaClo®)
  • Barbiturates, including:
o Amobarbital (Amytal®)
o Butalbital (Fioricet®, Fiorinal®)
o Pentobarbital (Nembutal®)
o Phenobarbital (Luminal®)
o Secobarbital (Seconal®)
  • Certain antibiotics or antifungals, such as:
o Clarithromycin (Biaxin®)
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Telithromycin (Ketek®)
 
  • Monoamine oxidase inhibitors (MAOIs), such as:
  • Narcotics or opiates, such as morphine, oxycodone (OxyContin®), or hydrocodone (Lortab®, Vicodin®)
 
  • Other antidepressant medications
 
  • Other benzodiazepines, such as:
o Chlordiazepoxide (Librium®)
 
  • Sleep medications.
     
(Drug Interactions With Chlordiazepoxide and Amitriptyline Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;