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Drug Interactions With Chlordiazepoxide and Amitriptyline

Certain Antibiotics or Antifungals
Some antibiotics and antifungal medications can increase the level of chlordiazepoxide and amitriptyline in your blood, which may increase your risk of side effects of chlordiazepoxide and amitriptyline. Talk to your healthcare provider before taking one of these medications while you are taking chlordiazepoxide and amitriptyline.
 
Cimetidine
Taking chlordiazepoxide and amitriptyline with cimetidine can increase the level of chlordiazepoxide and amitriptyline in your blood, potentially increasing your chance of side effects. Your healthcare provider may need to adjust your dose of these medications to prevent drug interactions from occurring.
 
Monoamine Oxidase Inhibitors
Combining chlordiazepoxide and amitriptyline with MAOIs can increase your chance of developing dangerous side effects. Do not take chlordiazepoxide and amitriptyline if you have taken an MAOI within the past two weeks.
 
Narcotics or Opiates
Taking an opiate or narcotic with chlordiazepoxide and amitriptyline can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before combining chlordiazepoxide and amitriptyline with an opiate or narcotic.
 
Other Antidepressant Medications
Combining an antidepressant with chlordiazepoxide and amitriptyline can increase your risk of side effects. Also, some antidepressants may increase the level of chlordiazepoxide and amitriptyline in your blood. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking chlordiazepoxide and amitriptyline with another antidepressant, as you may need to be monitored more closely.
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Drug Information on Chlordiazepoxide and Amitriptyline

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