Drug Interactions With Bupropion (Cont.)

 
Nicotine patches (Nicoderm CQ, Nicotrol)
Taking bupropion while using nicotine patches can cause high blood pressure. Your healthcare provider should monitor your blood pressure if you are taking these medications together.
 
Orphenadrine (Norflex)
While it is thought that orphenadrine may interact with bupropion, there have been no reports of such an interaction in actual patients. If you are taking orphenadrine along with bupropion, your healthcare provider may need to monitor you more closely and may need to adjust your doses of these medications.
 
Ritonavir (Norvir)
While it is thought that ritonavir may interact with bupropion, there have been no reports of such an interaction in actual patients. If you are taking ritonavir along with bupropion, your healthcare provider may need to monitor you more closely and may need to adjust your doses of these medications.
 
Steroids, Such as Prednisone or Methylprednisolone (Medrol)
Taking bupropion with intravenous or oral steroids can increase your risk of seizures. Talk with your healthcare provider before taking these medications together.
 
Theophylline
Taking bupropion with theophylline can increase your risk of seizures. Talk with your healthcare provider before taking bupropion and theophylline together.
 
Thiotepa
While it is thought that thiotepa may interact with bupropion, there have been no reports of such an interaction in actual patients. If you are taking thiotepa along with bupropion, your healthcare provider may need to monitor you more closely and may need to adjust your doses of these medications.
 

Final Thoughts on Drug Interactions With Bupropion

It is possible that not every bupropion drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions with bupropion that may apply to you.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;