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Drug Interactions With Bupropion

Beta Blockers
Bupropion may raise the levels of beta blockers in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor you more closely and may need to decrease your doses of beta blockers.
 
Certain Arrhythmia Medications
Bupropion may raise the levels of certain arrhythmia medications in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor you more closely -- especially when you are starting or stopping bupropion.
 
Clopidogrel
Clopidogrel may slow the metabolism of bupropion in the body, potentially leading to high levels of this medication and a potentially higher risk of side effects of bupropion. Check with your healthcare provider before taking these medications together.
  
Cyclophosphamide (Cytoxan)
While it is thought that cyclophosphamide may interact with bupropion, there have been no reports of such an interaction in actual patients. If you are taking cyclophosphamide along with bupropion, your healthcare provider may need to monitor you more closely and may need to adjust your doses of these medications.
 
Doxorubicin (Adriamycin, Doxil)
Doxorubicin may raise the level of bupropion in your blood, increasing your chances of side effects. Your healthcare provider may need to decrease your bupropion dose while you are taking doxorubicin.
 
Efavirenz (Sustiva)
Efavirenz may increase the metabolism of bupropion, leading to decreased levels of bupropion in the blood, and possibly to decreased effectiveness. Check with your healthcare provider before taking such medications together. You may need a higher bupropion dosage, although the maximum recommended dosage should not be exceeded, even if you are taking efavirenz.
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Bupropion HCl

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