Drug Interactions With Bupropion (Cont.)

Bupropion Interactions Explained

 
Alcohol
It is not recommended that you drink alcohol while taking bupropion. Combining alcohol and bupropion together may cause unwanted side effects (see Bupropion and Alcohol). However, since stopping alcohol abruptly while taking bupropion can increase your risk of seizures, talk with your healthcare provider before you stop drinking alcohol.
 
Other Antidepressants
Taking bupropion with other antidepressants may affect the level of bupropion and the other antidepressants in your blood, increasing your risk of side effects. Also, taking bupropion with other antidepressants may increase your risk of seizures. Talk with your healthcare provider before combining bupropion with other antidepressant medications.
 
You should not take bupropion along with other products containing bupropion, including Budeprion SR®, Buproban®, Budeprion XL®, Wellbutrin SR®, Wellbutrin XL®, and Zyban®.
 
Amantadine (Symmetrel)
Taking bupropion and amantadine together may increase your risk of side effects. Your healthcare provider may decide to start you at a lower bupropion dose if you are taking amantadine.
 
Antipsychotic Medications
Bupropion can raise the levels of some antipsychotic medications in your blood, increasing your risk of side effects. Also, taking bupropion with antipsychotic medications may increase your chances of developing seizures. Talk with your healthcare provider before taking these medications together.
 
Beta Blockers
Bupropion may raise the levels of beta blockers in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor you more closely and may need to decrease your doses of beta blockers.
(Drug Interactions With Bupropion Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;