Bupropion Interactions Explained
Alcohol
It is not recommended that you drink alcohol while taking
bupropion. Combining alcohol and bupropion together may cause unwanted side effects
(see Bupropion and Alcohol). However, since stopping alcohol abruptly while taking bupropion can increase your risk of
seizures, talk with your healthcare provider before you stop drinking alcohol.
Other Antidepressants
Taking bupropion with other
antidepressants may affect the level of bupropion and the other antidepressants in your blood, increasing your risk of side effects. Also, taking bupropion with other antidepressants may increase your risk of
seizures. Talk with your healthcare provider before combining bupropion with other antidepressant medications.
Amantadine (Symmetrel)
Taking bupropion and
amantadine together may increase your risk of side effects. Your healthcare provider may decide to start you at a lower bupropion dose if you are taking amantadine.
Antipsychotic Medications
Bupropion can raise the levels of some
antipsychotic medications in your blood, increasing your risk of side effects. Also, taking bupropion with antipsychotic medications may increase your chances of developing seizures. Talk with your healthcare provider before taking these medications together.
Beta Blockers
Bupropion may raise the levels of
beta blockers in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor you more closely and may need to decrease your doses of beta blockers.
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