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Drug Interactions With Bupropion

Bupropion Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when bupropion is combined with any of the drugs listed above.
 
Alcohol
It is not recommended that you drink alcohol while taking bupropion. Combining alcohol and bupropion together may cause unwanted side effects (see Bupropion and Alcohol). However, since stopping alcohol abruptly while taking bupropion can increase your risk of seizures, talk with your healthcare provider before you stop drinking alcohol.
 
Other Antidepressants
Taking bupropion with other antidepressants may affect the level of bupropion and the other antidepressants in your blood, increasing your risk of side effects. Also, taking bupropion with other antidepressants may increase your risk of seizures. Talk with your healthcare provider before combining bupropion with other antidepressant medications.
 
You should not take bupropion along with other products containing bupropion, including Aplenzin®, Budeprion SR®, Buproban®, Forfivo™ XL, Budeprion XL®, Wellbutrin SR®, Wellbutrin XL®, Wellbutrin, and Zyban®.
 
Amantadine (Symmetrel)
Taking bupropion and amantadine together may increase your risk of side effects. Your healthcare provider may decide to start you at a lower bupropion dose if you are taking amantadine.
 
Antipsychotic Medications
Bupropion can raise the levels of some antipsychotic medications in your blood, increasing your risk of side effects. Also, taking bupropion with antipsychotic medications may increase your chances of developing seizures. Talk with your healthcare provider before taking these medications together.
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