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Drug Interactions With Bupropion XL

Levodopa
Taking bupropion XL and levodopa together may increase your risk of side effects. To prevent this, your healthcare provider may decide to start you at a lower dose of bupropion XL if you are taking levodopa.
 
Monoamine Oxidase Inhibitors
You should not take bupropion XL if you have taken an MAOI within the past 14 days, due to an increased risk of potentially dangerous side effects.
 
Nelfinavir
Nelfinavir may interact with bupropion XL, although there have been no reports of such an interaction in actual patients. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
 
Nicotine Patches
If bupropion XL is taken while using nicotine patches, this can cause high blood pressure. Your healthcare provider should monitor your blood pressure if you are taking these medications together.
 
Orphenadrine
Orphenadrine may interact with bupropion XL, although there have been no reports of such an interaction in actual patients. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
 
Ritonavir (Norvir) or Lopinavir and Ritonavir (Kaletra)
Ritonavir (whether taken alone or with lopinavir) may increase the metabolism of bupropion XL, leading to decreased levels of bupropion XL in the blood and possibly to decreased effectiveness. Check with your healthcare provider before taking such medications together. You may need a higher bupropion XL dosage, although the maximum recommended dosage should not be exceeded, even if you are taking ritonavir.
  
Steroids
Taking bupropion XL with intravenous or oral steroids can increase your risk of seizures. Talk to your healthcare provider before taking these medications together.
 
Tamoxifen (Nolvadex)
At least theoretically, bupropion XL could cause tamoxifen to be less effective. Check with your healthcare provider before taking these medications together.
  
Theophylline
Combining bupropion XL with theophylline can increase your risk of seizures. Talk to your healthcare provider before taking these medications together.
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