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Drug Interactions With Bupropion XL

Bupropion XL Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when bupropion XL is combined with any of the drugs listed above.
 
Alcohol
Alcohol and bupropion XL should not be combined. Taking the two together may cause unwanted side effects (see Wellbutrin XL and Alcohol). However, because stopping alcohol abruptly while taking the medication can increase your risk of seizures, talk to your healthcare provider before you stop drinking alcohol.
 
Other Antidepressants
Taking bupropion XL with other antidepressants may affect the level of bupropion XL and the other antidepressant in your blood, increasing your risk of side effects. Also, taking bupropion XL with other antidepressants may increase your risk of seizures. Talk with your healthcare provider before combining bupropion XL with other antidepressant medications.
 
You should not take bupropion XL along with other products containing bupropion, including Aplenzin™, Budeprion SR®, Budeprion XL®, Buproban®, Wellbutrin®, Wellbutrin SR®, Wellbutrin XL, and Zyban®.
 
Amantadine
Combining bupropion XL and amantadine may increase your risk of side effects. Your healthcare provider may decide to start you at a lower dose of bupropion XL if you are taking amantadine to avoid this drug interaction.
 
Antipsychotic Medications
Bupropion XL can increase the level of some antipsychotic medications in your blood, which may increase your risk of side effects. Also, taking bupropion XL with antipsychotic medications may increase your chance of seizures. Talk with your healthcare provider before taking these medications together.
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Bupropion XL (Wellbutrin XL)

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