Prior to taking bupropion SR, there are some precautions and warnings to be aware of with the medication. Taking bupropion SR can increase your risk of suicidal thoughts or behavior, potentially cause seizures, and may not be safe to take while you are pregnant or breastfeeding. Therefore, talk to your healthcare provider about any precautions and warnings with bupropion SR that may apply to your situation, as there are certain situations where you should not take the medication.

• Seizures or epilepsy (see Wellbutrin Seizures)
• A brain tumor
• A history of head trauma or brain injury
• Diabetes
• An eating disorder, such as bulimia or anorexia
• Bipolar disorder (also known as manic depression) or a family history of bipolar disorder 
• Heart disease
• A recent history of a heart attack
• A history of suicide attempts or suicidal thoughts
• Liver problems, including liver failure or cirrhosis
• Kidney disease, including kidney failure (renal failure)
• Any allergies, including allergies to food, dyes, or preservatives.
   

• Are pregnant or thinking of becoming pregnant
• Are breastfeeding
• Drink alcohol regularly.