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Precautions and Warnings With Bupropion SR

Some Precautions and Warnings With Bupropion SR

Some warnings and precautions to be aware of with bupropion SR include:
  • Antidepressants (including bupropion SR) may increase the risk of suicidal thoughts or behavior in children, teenagers, and adults (see Antidepressants and Suicide for more information). Therefore, if you notice any changes in symptoms or new symptoms while taking bupropion SR, talk with your healthcare provider immediately. These symptoms may include: anxiety, hostility, agitation, panic, restlessness, hallucinations, extreme hyperactivity, and suicidal thoughts or behavior (see Wellbutrin SR and Suicide for more information).
  • Before prescribing bupropion SR for depression, your healthcare provider should make sure that you do not have bipolar disorder (instead of depression). The symptoms of bipolar disorder and depression are sometimes very similar, and bupropion SR can cause problems in people with bipolar disorder.
  • Bupropion SR can increase the risk of seizures. As a result, there are certain people who should not take bupropion SR, including people with:




  • To avoid seizures, you should not take more than 400 mg of bupropion SR per day (for treating depression), and each individual dose should not be greater than 200 mg. For smoking cessation, the maximum dose is 300 mg per day (and 150 mg per dose) (see Bupropion SR Dosing).
  • Bupropion SR should not be used right after a heart attack. Also, there is some evidence that bupropion SR can cause irregular heart rhythms (arrhythmias) in people with heart disease.
  • Bupropion SR can cause liver damage. Also, because the liver and kidneys aid in removing bupropion SR from the blood, you should talk with your healthcare provider before taking bupropion SR if you have liver or kidney problems.


  • Bupropion SR has been reported to cause false positives on some amphetamine drug screening tests, even after people have stopped taking bupropion SR. 


  • Bupropion SR can cause insomnia, agitation, hallucinations, confusion, and other mental problems, especially in people just starting the medicine. Tell your healthcare provider if you are experiencing any of these problems.
  • Bupropion SR can cause weight loss, especially when used to treat depression. This can be a problem for some people, especially those who are underweight (see Wellbutrin SR and Weight Loss for more information).
  • Bupropion SR can cause allergic reactions. Tell your healthcare provider if you have signs of an allergic reaction while taking bupropion SR, including an unexplained skin rash, itching, hives, trouble breathing, or unexplained swelling.
  • Sometimes bupropion SR can cause high blood pressure (hypertension), especially in people using nicotine patches. Your healthcare provider should monitor your blood pressure if you are taking bupropion SR. It is not known if bupropion SR causes problems in people who have heart disease or who have recently had a heart attack.
  • Bupropion SR is a considered a pregnancy Category C medication. This means that bupropion SR may not be safe to use during pregnancy. Talk with your healthcare provider about the risks and benefits of using bupropion SR during pregnancy (see Wellbutrin SR and Pregnancy or Zyban and Pregnancy for more information).
  • Bupropion SR passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using bupropion SR (see Bupropion and Breastfeeding).
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