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Drug Interactions With Bupropion SR

Beta Blockers
Bupropion SR may raise the levels of beta blockers in your blood, increasing your risk of side effects. If you are taking bupropion SR along with a beta blocker, your healthcare provider may need to monitor you more closely and may need to decrease your dose of the beta blocker.
 
Certain Arrhythmia Medications
Bupropion SR may raise the levels of certain arrhythmia medications in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to monitor you more closely, especially when starting or stopping bupropion SR.
 
Clopidogrel
Clopidogrel may slow the metabolism of bupropion SR in the body, potentially leading to high levels of bupropion SR and a potentially higher risk of bupropion SR side effects. Check with your healthcare provider before taking these medications together.
  
Cyclophosphamide (Cytoxan)
While it is thought that cyclophosphamide may interact with bupropion SR, there have been no reports of such an interaction in actual patients. If you are taking cyclophosphamide along with bupropion SR, your healthcare provider may need to monitor you more closely and may need to adjust your doses of these medications.
 
Doxorubicin (Adriamycin, Doxil)
Doxorubicin may raise the level of bupropion SR in your blood, increasing your chances of side effects. Your healthcare provider may need to decrease your bupropion SR dose while you are taking doxorubicin.
 
Efavirenz (Sustiva)
Efavirenz may increase the metabolism of bupropion SR, leading to decreased levels of bupropion SR in the blood, and possibly to decreased effectiveness. Check with your healthcare provider before taking such medications together. You may need a higher bupropion SR dosage, although the maximum recommended dosage should not be exceeded, even if you are taking efavirenz.
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