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Drug Interactions With Bupropion SR

Bupropion SR Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when bupropion SR is combined with any of the drugs listed above.
 
Alcohol
It is not recommended that you drink alcohol while taking bupropion SR. Combining alcohol and bupropion SR together may cause unwanted side effects (see Wellbutrin SR and Alcohol). However, you should be sure to talk with your healthcare provider before you stop drinking alcohol, as stopping alcohol abruptly while taking bupropion SR can increase your risk of seizures.
 
Other Antidepressants
Taking bupropion SR with other antidepressants may affect the levels of bupropion SR and the other antidepressants in your blood, increasing your risk of side effects. Also, taking bupropion SR with other antidepressants may increase your risk of seizures. Talk with your healthcare provider before combining bupropion SR with other antidepressant medications.
 
You should not take bupropion SR along with other products containing bupropion, including Aplenzin™, Budeprion SR, Buproban®, Forfivo™ XL, Budeprion XL®, Wellbutrin®, Wellbutrin SR®, Wellbutrin XL®, and Zyban®.
 
Amantadine (Symmetrel)
Taking bupropion SR and amantadine together may increase your risk of side effects. Your healthcare provider may decide to start you at a lower bupropion SR dose if you are taking amantadine.
 
Antipsychotic Medications
Bupropion SR can raise the levels of some antipsychotic medications in your blood, increasing your risk of side effects. Also, taking bupropion SR with antipsychotic medications may increase your chances of seizures. Talk with your healthcare provider before taking these medications together.
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