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Bupropion SR

Clinical Effects

Many studies have looked at bupropion SR for treating depression or for helping with smoking cessation.
Studies of Wellbutrin (the short-acting version of bupropion SR) have shown that it is effective for depression treatment. While it is assumed that bupropion SR is equally effective for depression, these same studies have not been performed with it.
Smoking Cessation
Several studies have shown that bupropion SR can help people stop smoking. In one study, up to 36 percent of people taking this drug were able to stop smoking for at least a month, compared to only 17 percent of those not taking it. In another study, combining bupropion SR with nicotine patches was even more effective: Up to 58 percent of people using bupropion SR along with nicotine patches were able to quit smoking for at least one month, compared to 23 percent of those not taking either medication.
Studies have shown that bupropion SR also helps to reduce nicotine withdrawal symptoms, such as:
  • Irritability
  • Frustration
  • Anger
  • Anxiety
  • Trouble concentrating
  • Restlessness
  • Depression.
Studies have also shown that people who continue to take bupropion SR after they stop smoking are less likely to start smoking again.

When and How to Take Bupropion SR

Some general considerations for when and how to take bupropion SR include the following:
  • Bupropion SR comes in tablet form. It is taken by mouth, usually twice a day.
  • Be sure to swallow the tablets whole. They should not be cut, crushed, broken, or chewed.
  • You can take bupropion SR with or without food. If the medication bothers your stomach, try taking it with food.
  • Bupropion SR should be taken at the same times each day to maintain an even level in your blood.
  • For the medication to work properly, it must be taken as prescribed. Bupropion SR will not work if you stop taking it.
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