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Precautions and Warnings With Bupropion Hydrobromide

Specific Warnings and Precautions With Bupropion Hydrobromide

Some warnings and precautions to be aware of prior to taking this drug include the following:
  • Antidepressants (including bupropion hydrobromide) may increase the risk of suicidal thoughts or behavior in children, teenagers, and adults (see Depression and Suicide and Antidepressants and Suicide for more information). Therefore, if you notice any changes in symptoms or new symptoms, immediately notify your healthcare provider. Some of these symptoms may include:
    • Anxiety
    • Hostility
    • Agitation
    • Panic
    • Restlessness
    • Hallucinations
    • Extreme hyperactivity
    • Suicidal thoughts or behavior.
  • Before prescribing bupropion hydrobromide for depression, your healthcare provider should make sure that you do not have bipolar disorder (instead of depression). Sometimes, the symptoms of bipolar disorder and depression are very similar, and bupropion hydrobromide can cause problems in people with bipolar disorder.
  • Bupropion hydrobromide can increase the risk of seizures (see Aplenzin Seizures). Because of this, there are certain people who should not take bupropion hydrobromide, including people with:
Also, people taking certain medications (see Drug Interactions With Bupropion Hydrobromide) have a higher risk of seizures. Abruptly stopping alcohol or sedative medications can also increase your risk of seizures.
  • To avoid seizures, you should not take more than 522 mg of bupropion hydrobromide per day.
  • Bupropion hydrobromide should not be used right after a heart attack. Also, there is some evidence that this antidepressant can cause irregular heart rhythms (arrhythmias) in people with heart disease.
  • Bupropion hydrobromide can cause liver damage. Also, because the liver and kidneys help to remove bupropion hydrobromide from the blood, you should talk to your healthcare provider before taking this medication if you have liver or kidney problems.
  • Bupropion hydrobromide can cause insomnia, agitation, hallucinations, confusion, and other mental problems, especially in people just starting the medicine. Tell your healthcare provider if you are experiencing any of these problems.
  • Bupropion hydrobromide can cause weight loss. This can be a problem for some people, especially those who are underweight (see Aplenzin and Weight Loss for more information).
  • Bupropion hydrobromide can cause allergic reactions. Tell your healthcare provider if you have signs of an allergic reaction, including an unexplained skin rash, itching, hives, trouble breathing, or unexplained swelling.


  • Bupropion hydrobromide has been reported to cause false positives on some amphetamine drug screening tests, even after people have stopped taking bupropion hydrobromide. 


  • Sometimes, bupropion hydrobromide can cause high blood pressure (hypertension), especially in people using nicotine patches. Your healthcare provider should monitor your blood pressure if you are taking this antidepressant. It is not known if bupropion hydrobromide causes problems in people who have heart disease or who have recently had a heart attack.
  • Bupropion hydrobromide is considered a pregnancy Category C medication. This means that it may not be safe to use during pregnancy. Talk to your healthcare provider about the risks and benefits of using bupropion hydrobromide during pregnancy (see Aplenzin and Pregnancy for more information).
  • Bupropion hydrobromide passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using this antidepressant (see Aplenzin and Breastfeeding).
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