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Drug Interactions With Bupropion Hydrobromide

Beta Blockers
Bupropion hydrobromide may increase the level of beta blockers in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and may need to decrease your dose of beta blockers.
 
Certain Arrhythmia Medications
Bupropion hydrobromide may increase the level of certain arrhythmia medications in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely, especially when starting or stopping bupropion hydrobromide.
 
Clopidogrel
Clopidogrel may slow the metabolism of bupropion hydrobromide in the body, potentially leading to high levels of bupropion hydrobromide and a potentially higher risk of bupropion hydrobromide side effects. Check with your healthcare provider before taking these medications together.
  
Cyclophosphamide
It is thought that cyclophosphamide may interact with bupropion hydrobromide, although the actual significance of this interaction is unknown. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications.
 
Doxorubicin
Doxorubicin may increase the level of bupropion hydrobromide in your blood, increasing your chance of side effects. Your healthcare provider may need to decrease your bupropion hydrobromide dose while you are taking doxorubicin.
 
Efavirenz
It is thought that efavirenz may interact with bupropion hydrobromide, although the actual significance of this interaction is unknown. Your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
 
Levodopa
Taking bupropion hydrobromide and levodopa may increase your risk of side effects. Your healthcare provider may decide to start you at a lower bupropion hydrobromide dose if you are taking levodopa.
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