Drug Interactions With Amphetamine-Dextroamphetamine Extended Release (Cont.)

 
Norepinephrine (Levophed)
Taking amphetamine-dextroamphetamine extended release and norepinephrine together can cause an increase in side effects, particularly increased blood pressure and heart rate. Your healthcare provider may need to adjust your dose of these drugs.
 
Phenobarbital (Luminal)
Taking amphetamine-dextroamphetamine extended release and phenobarbital together can cause phenobarbital to be absorbed into the body more slowly, possibly making it less effective. Taking the two medications together can also cause phenobarbital to be more effective at preventing seizures. It is difficult to predict whether taking the medications together will increase or decrease the effectiveness of phenobarbital. Your healthcare provider may need to adjust your dose of these drugs.
 
Phenytoin (Dilantin)
Taking amphetamine-dextroamphetamine extended release and phenytoin together can cause phenytoin to be absorbed into the body more slowly, possibly making it less effective. Taking the two medications together can also cause phenytoin to be more effective at preventing seizures. It is difficult to predict whether taking the medications together will increase or decrease the effectiveness of phenytoin. Your healthcare provider may need to adjust your dose of these drugs.
 
Propoxyphene (Darvocet, Darvon)
Taking amphetamine-dextroamphetamine extended release and very high doses of propoxyphene together can cause life-threatening side effects, such as seizures. Do not take amphetamine-dextroamphetamine extended release and very high doses of propoxyphene together unless your healthcare provider specifically instructs you to do so.
 
Reserpine
Taking amphetamine-dextroamphetamine extended release and reserpine together can cause a decrease in the amount of amphetamine-dextroamphetamine extended release in the blood, possibly making amphetamine-dextroamphetamine extended release less effective. Your healthcare provider may need to adjust your dose of these drugs.
(Drug Interactions With Amphetamine-Dextroamphetamine Extended Release Continued: Page 5)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;