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Side Effects of Amoxapine

Amoxapine Side Effects to Report

There are a number of less common but more serious side effects with amoxapine that you should report to your healthcare provider, including, but not limited to:
  • Very high fever
  • Change in heart rhythm (arrhythmia)
  • Fast heart rate (tachycardia) or feelings of a rapidly or forcefully beating heart (palpitations)
  • Seizures
  • Unusual muscle twitches or movements or muscle tension
  • Worsening confusion, delusions, or hallucinations
  • Signs of an allergic reaction, including unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing
  • Any breast changes, including breast enlargement or breast discharge
  • Suicidal thoughts or behavior (see Amoxapine and Suicide)
  • Hostility or aggressiveness
  • Engaging in unusual or dangerous activities
  • Extreme elation or feeling of happiness that may switch back and forth with a depressed or sad mood
  • Other unusual changes in behavior
  • Difficulty sleeping
  • Worsening anxiety, agitation, or panic attacks.

Rare Side Effects Seen With Amoxapine

There are other possible amoxapine side effects that can occur. In studies, these side effects occurred in 1 percent (or fewer) of patients taking amoxapine. For these side effects, it is difficult to tell whether they are actually caused by amoxapine itself or something else.
Some of these rare but possible amoxapine side effects include, but are not limited to:
  • Difficulty passing urine
  • Stuffy nose
  • Low blood pressure (hypotension)
  • Sensitivity to the sun
  • Abnormal sensations, such as burning, tingling, or pricking (paresthesias)
  • Ringing of the ears (tinnitus)
  • Problems concentrating
  • Vomiting
  • Gas
  • Diarrhea
  • Changes in sex drive
  • Painful ejaculation
  • Impotence, also known as erectile dysfunction or ED (see Amoxapine Sexual Side Effects)
  • Weight gain or weight loss
  • Hair loss.
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