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Amoxapine Sexual Side Effects

During depression treatment with amoxapine, sexual side effects can occur. These sexual problems may include changes in sex drive, painful erection, or impotence. If you develop any amoxapine sexual side effects, let your healthcare provider know so he or she can recommend an erectile dysfunction medication, adjust your amoxapine dosage, or prescribe another antidepressant.

Amoxapine Sexual Side Effects: An Overview

Amoxapine (Asendin®) is a prescription medication that is used for the treatment of depression. It is part of a group of medications called tricyclic antidepressants. As with all medicines, amoxapine has possible side effects. Some of these side effects can affect a person's sexual well-being. In the case of amoxapine, there have been a few sexual side effects reported (although how frequently they occurred was not reported).

Sexual Side Effects With Amoxapine

In clinical studies of using amoxapine to treat depression, the following sexual side effects were reported:
  • Changes in sex drive (libido), including increased sex drive or decreased sex drive.
  • Impotence. Impotence is usually defined as a total inability to achieve erection, an inconsistent ability to do so, or a tendency to sustain only brief erections. Ultimately, impotence is the repeated inability to get or keep an erection firm enough for sexual intercourse. Impotence is also known as erectile dysfunction (or ED for short).
  • Painful ejaculation.
These sexual side effects occurred in less than 1 percent of people taking amoxapine.

Amoxapine and Sexual Side Effects: Suggestions

It is impossible for your healthcare provider to know beforehand whether you will develop any sexual side effects while taking amoxapine. Also, if a person does develop sexual side effects, it is difficult to know whether these problems are caused by another condition or amoxapine itself.
However, if you develop any sexual side effects while taking amoxapine, make sure to talk with your healthcare provider. There is treatment that he or she may be able to recommend, such as an erectile dysfunction medication. Depending on how severe your sexual side effects are, he or she may also recommend that you adjust your amoxapine dosage or try another medication for depression.
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