Amoxapine Dosing

Amoxapine dosing recommendations typically start at 50 mg two or three times daily. Based on your response to the medication, your healthcare provider can increase or decrease your dosage as needed. After you reach a stable daily dose of amoxapine, he or she may also recommend that you take your dosage all at once at bedtime. For elderly people who are first beginning depression treatment with amoxapine, dosing may start at 25 mg two or three times a day.

 

Amoxapine Dosage: An Overview

The dose of amoxapine (Asendin®) that your healthcare provider prescribes will vary depending on a number of factors, including:
 
  • Your age
  • The medical condition being treated
  • Other medical conditions you may have
  • Other medications you may currently be taking.
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As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

Amoxapine Dosing for Depression

The recommended starting amoxapine dose for depression treatment is 50 mg two or three times daily. Your healthcare provider may increase your dose if necessary to control depression symptoms or decrease your dose if you are experiencing side effects. After you have reached a stable dose, your healthcare provider may recommend taking your dose all at once at bedtime (if you are taking 300 mg or less). If you are taking more than 300 mg, you will still need to split up your doses throughout the day.
 
Alternatively, your healthcare provider may decide to start you at amoxapine 300 mg once a day (at bedtime), although you would be more likely to experience drowsiness when starting at this dose.
 
In general, elderly people are started at a lower amoxapine dose (25 mg two or three times daily), as they may be more sensitive to amoxapine side effects.
 
(Amoxapine Dosing Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;